MOTS-C 30mg

MOTS-C 30mg
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MOTS-c: Pharmaceutical grade mitochondrial peptide for research

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a recently discovered mitochondrial peptide that has been of major scientific interest since its characterization in 2015. Peptivia Lab offers a pharmaceutical grade, HPLC-tested formulation, assembled and shipped from Canada for laboratory research.

 

What is MOTS-c?

MOTS-c is a 16-amino acid peptide encoded by a small open reading frame located in the mitochondrial MT-RNR1 (12S rRNA) gene. Unlike the vast majority of cellular proteins which are encoded by nuclear DNA, MOTS-c is one of the few peptides encoded directly by the mitochondrial genome, making it a unique object of research.

It was first characterized in 2015 by the team of Dr. Changhan David Lee and Dr. Pinchas Cohen at the University of Southern California (USC). Their publication in Cell Metabolism demonstrated the role of this peptide in the regulation of cellular metabolism and energy homeostasis.

Since then, MOTS-c has been studied as a mitochondria-to-nucleus retrograde signal, meaning it transmits information from the mitochondria to the cell nucleus in response to metabolic stress.

Mechanisms of action studied in research

Scientific literature documents several mechanisms of interest studied in vitro and in animal models:

  • AMPK activation (AMP-activated protein kinase) — a central enzyme in cellular energy sensing, studied as the primary target of MOTS-c
  • Regulation of folate metabolism and the methionine cycle, involved in energy production
  • Mitochondria-to-nucleus retrograde signaling — nuclear translocation demonstrated under metabolic stress conditions (Kim et al., 2018)
  • Modulation of nuclear gene expression in response to metabolic stress
  • Glucose homeostasis — documented effects on insulin sensitivity in murine models (Lee et al., 2015)
  • Lipid metabolism — studied role in adipose tissue homeostasis (Lu et al., 2019)
  • Osteogenic differentiation — TGF-β/Smad pathway studied in mesenchymal stem cells (Hu & Chen, 2018)

These mechanisms are reported in scientific literature and are presented for informational purposes only, within a research context.

Research Areas

MOTS-c is the subject of active studies in several cutting-edge scientific fields:

  • Research on mitochondrial-derived peptides (MDPs)
  • Studies on cellular aging and longevity (Fuku et al., Reynolds et al.)
  • Research on metabolic homeostasis and insulin resistance
  • Studies on adipose tissue metabolism
  • Research on age-related physical decline (murine models)
  • Experimental cardiovascular studies (Qin et al., 2018)
  • Research on bone health and osteogenesis (Hu & Chen, 2018)
  • Studies on exercise and muscle metabolism

MOTS-c: A peptide encoded by mitochondria

What makes MOTS-c particularly unique in research is its origin: it belongs to the still little-explored family of mitochondrial-derived peptides (MDPs). This family also includes:

  • Humanin — the first MDP discovered, studied in neuroprotection
  • SHLP1-6 (Small Humanin-Like Peptides)
  • MOTS-c — studied primarily for metabolism and longevity

The discovery of these peptides has opened a new field of research into mitochondria-to-nucleus communication and the regulatory role of mitochondria in global cellular physiology.

Technical specifications

  • Available dosages: several formats in lyophilized vials (see options above)
  • Purity: Over 99%, HPLC-tested
  • Form: Lyophilized peptide (powder)
  • Length: 16 amino acids
  • Genomic origin: open reading frame of the mitochondrial MT-RNR1 gene (12S rRNA)
  • Classification: mitochondrial-derived peptide (MDP)
  • Certificate of Analysis (COA): Available upon request
  • Packaging: Sealed glass vial, sterile handling recommended
  • Origin: Pharmaceutical-grade peptide synthesis

Reconstitution and Storage

MOTS-c is provided in lyophilized form and must be reconstituted with Bacteriostatic Water (not included).

Before reconstitution: store the closed vial in the freezer (-20°C) for optimal long-term stability, protected from light.

After reconstitution: Store in the refrigerator (2-8°C). Use the solution within 60 days.

Why bacteriostatic water? It contains 0.9% benzyl alcohol which inhibits bacterial growth, allowing for safer and longer preservation of your research peptide solutions.